There’s a lot of backtracking and in-world puzzle-solving in Resident Evil games, and Resident Evil 3 Remake is no different. With this game, some of the puzzles from the original version have returned in some form, but most of the content has changed pretty dramatically. The layout of the city has changed a bit, and you’re going to have to learn some new puzzles. The much flashier RE Engine also makes the game much prettier this time around. All in all, it’s a really solid remake. Of course, some things have remained, like the trusty and powerful Shotgun, the process of upgrading weapons is much the same as it was in the classic games as well. That means the Red Dot Sight in Resident Evil 3 Remake is in the game, and Jill can make lethal use of it.
You can unlock the Red Dot Sight in Resident Evil 3 Remake fairly early on in the story. Carlos shows up and asks Jill to head to the power substation to aid in their escape of the ruined Raccoon City. On the way, there are various puzzles to solve and items to pick up. One of these involves the Redstone Pharmacy, and area that contains both some helpful items and the solution to a puzzle. The puzzle is finding the safe combination
The pharmacy is across the street from the goal, the safe which contains the Red Dot Sight in Resident Evil 3 Remake.
To get to the Pharmacy is a bit of a journey. After you progress toward the alley that’s on fire in the first downtown area, some zombies will come crashing through a fence blocking your path. A nearby red barrel should be shot to take them down as a group. Don’t waste your ammo shooting them one at a time.
Head down the steps and into Moon’s Donuts, and be sure to use the Safe Room there. Leave through the back door and you will see another group of undead that should be baited into the nearby red barrel. At the end of this street is the pharmacy you’re looking for. Within there will be various items: a green herb is sitting on the counter; and some gunpowder is on a shelf; the real goal is on the wall.
Look at the Aqua Cure poster on the wall. On that poster will be three numbers circled in red. This is the safe combination you need to open the safe. The combination is random each time you play through the game. The combination should always be three single-digit numbers though.
Once you have the combo, head across the street and up the fire escape. Take out the zombie at the entrance to this building and had towards the rear of the building. The safe will be there against the wall. Enter the combination for your game in a Left-Right-Left manner to open it.