Pathfinder: Wrath of the Righteous puts a great many challenges in front of the player. The enemies you fight will be able to throw out various spells and curses that can apply effects permanently. Diseases and permanent conditions in Pathfinder: Wrath of the Righteous can be very crippling in a variety of ways.
You can of course heal less serious wounds and other effects. The party will invariably become cursed and screwed up in various ways. There’s a bunch of spells that can help with diseases. Sometimes you will get these problematic long-term diseases applied, so these spells are useful. You’ll have to remove these effects using specific healing spells. Here’s the best way to remove diseases and other permanent conditions in Pathfinder: Wrath of the Righteous.
The biggest reason you want to do this ASAP is that diseases can often affect ability scores. Losing out on CON or STR bonuses can be very detrimental to your melee characters. Spellcasters losing points in their relevant stat will cause a huge problem if you need to cast a high-level spell.
Check the character sheet of any party member to see their current status. Any afflicted conditions will be listed here. If your character has an effect listed here after battles end, that likely means you got hit with permanent conditions in Pathfinder: Wrath of the Righteous.
The best way to remove many of these negative effects is to use the level two spell, Remove Disease. This spell is a class feature of both the Witch and Druid, and is very useful to have on reserve for long-term adventures. If you have a different party makeup, you can use a scroll that has this spell on it to have any spellcaster use it. You do lose the scroll, but it’s worth it to keep your party alive.
Another option is a long rest. Use the Rest key and click on the tent to do that. This will refill any lost HP or spell slots. Sometimes, you can also get rid of certain conditions.